Diffuse Midline Glioma H3 K27 Altered C5669877
An aggressive brain tumor affecting central brain structures, occurring in both children and adults. Prognosis is poor; radiation is standard treatment with limited benefit.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- fatal
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bilateral motor weakness
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Cranial nerve deficits
Hydrocephalus
Ataxia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Focal Radiation Therapy
Precision radiation targeting the tumor site to reduce growth and alleviate mass effect symptoms. Typically delivered as external beam radiation over several weeks.
Image-guided procedure with follow-up care
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Targeted Biologic Therapy
Systemic treatment using molecularly targeted agents designed to address specific genetic alterations. Treatment requires regular monitoring for response and side effects.
Additional treatment options
Serial Imaging Surveillance
Regular MRI assessments to track disease progression and treatment response, guiding ongoing clinical decisions and treatment modifications.
monitoringNeuropsychological Support
Comprehensive psychological services addressing cognitive changes, emotional adjustment, and quality of life concerns associated with diagnosis and treatment.
psychologicalPalliative Care Integration
Specialized supportive care focused on symptom management, pain control, and psychosocial support for patients and families facing serious illness.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Diffuse Midline Glioma H3 K27 Altered C5669877?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Louis DN, Wesseling P, Aldape K, et al. cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors. Neuro Oncol. 2020.
Cohen KJ, Heideman RL, Zhou T, et al. Childhood diffuse intrinsic pontine glioma: a 20-year institutional experience. J Neurooncol. 2019.
Johannesen TB, Ancillet EG, Grill J, et al. Onalespib and radiotherapy in H3 K27M-mutant diffuse midline glioma: a phase 1/2 trial. Lancet Oncol. 2022.
Karremann M, Rausche U, Rothauge OF, et al. Diffuse midline gliomas with H3 K27M mutation: update on molecular pathology and treatment approaches. Neuropathology. 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy