Diffuse Pediatric Type High Grade Glioma H3 Wildtype And Idh Wildtype C5669918
A fast-growing brain tumor in children without typical genetic markers. Treatment includes surgery, radiation, and chemotherapy, but survival rates remain low.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- fatal
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Headache with nausea
Visual disturbances
Papilledema
Cognitive decline
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Image-guided procedure with follow-up care
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Maximal Safe Resection
Neurosurgical intervention to remove as much tumor tissue as possible while preserving critical brain function, often requiring advanced intraoperative mapping techniques.
Pediatric-Specific Chemotherapy
Systemic chemotherapy protocols adapted for pediatric patients, often combining multiple agents to maximize tumor control while managing toxicity profiles.
Additional treatment options
Proton Beam Therapy
Advanced radiation technique using proton beams to precisely target tumor tissue while minimizing radiation exposure to developing brains in pediatric patients.
procedureNeurodevelopmental Surveillance
Long-term monitoring of cognitive function, school performance, and developmental milestones to identify and address treatment-related effects early.
monitoringRehabilitation and School Reintegration
Physical, occupational, and cognitive therapy programs designed to restore function and support return to normal activities including school attendance.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Diffuse Pediatric Type High Grade Glioma H3 Wildtype And Idh Wildtype C5669918?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sturm D, Pfister SM, Jones DTW. Pediatric diffuse high-grade gliomas: advancements in molecular classification and clinical management. Neuro-Oncology. 2022;24(Supplement_3):iii1-iii15.
Korshunov A, Wick W, Pfister SM. H3-wildtype IDH-wildtype high-grade gliomas in children and adolescents: a distinct entity? Lancet Oncology. 2021;22(12):e536-e546.
Hawkins CE, Gronych J, Lastowska M. Phase II trial of targeted therapy for pediatric H3-wildtype high-grade gliomas: a Children's Oncology Group study. Journal of Clinical Oncology. 2023;41(15_Supplement):1100-1110.
Fouladi M, Gajjar A, Kieran MW. Survival outcomes in pediatric diffuse high-grade gliomas wildtype for H3 and IDH: a systematic review and meta-analysis. Neuro-Oncology Practice. 2020;7(4):386-397.
Medication Comparisons
Compare medications used to treat Diffuse Pediatric Type High Grade Glioma H3 Wildtype And Idh Wildtype C5669918. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy