Diminished Mlh1 Expression C6055317
MLH1 is a gene critical for DNA repair. Reduced expression increases susceptibility to certain cancers, especially colorectal and endometrial cancers. Genetic counseling and enhanced cancer screening are typically recommended for affected individuals.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Blood in stool
Abdominal pain
Iron‑deficiency anemia
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Change in bowel habits (e.g., diarrhea or constipation)
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Intensive colonoscopic surveillance
Regular colonoscopy screening every 1-2 years starting at age 20-25 or 2-5 years before youngest family case. Early detection of neoplastic lesions allows for timely intervention.
Prophylactic colectomy
Risk-reducing surgical removal of the colon for high-risk patients with extensive family history or unresectable lesions. Consideration after genetic counseling and thorough risk assessment.
Additional treatment options
Aspirin chemoprevention
Long-term low-dose aspirin therapy has shown reduction in colorectal cancer risk in Lynch syndrome carriers. Mechanism involves COX-2 inhibition and reduction of inflammatory pathways.
medicationMediterranean diet adoption
Plant-based diet rich in fruits, vegetables, whole grains, and olive oil may reduce colorectal cancer risk. Limits processed meats and red meat consumption.
dietaryGenetic counseling and psychological support
Comprehensive pre-test and post-test genetic counseling to understand hereditary cancer risk, implications for family members, and coping strategies for lifelong surveillance.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Diminished Mlh1 Expression C6055317?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy