Diminished Msh2 Expression C6055318
MSH2 is a key DNA mismatch repair gene. When its expression is reduced, cells accumulate genetic errors that can lead to tumor development. This is associated with Lynch syndrome and higher cancer risk, requiring surveillance and preventive strategies.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Rectal bleeding
Unexplained weight loss
Iron deficiency anemia
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Persistent diarrhea
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Enhanced endoscopic surveillance program
Annual colonoscopy with chromoendoscopy for high-quality visualization. Includes endometrial, ovarian, gastric, and urinary tract screening protocols.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Risk-reducing gynecologic surgery
Prophylactic hysterectomy and bilateral salpingo-oophorectomy after childbearing completed, significantly reducing endometrial and ovarian cancer risk in MSH2 carriers.
Additional treatment options
NSAID-based chemoprevention
Regular use of NSAIDs such as sulindac or celecoxib may reduce adenoma formation. Prescribed as adjunct to surveillance in high-risk individuals.
medicationSmoking cessation and alcohol moderation
Tobacco cessation critical as smoking significantly increases colorectal cancer risk in Lynch syndrome. Limiting alcohol to moderate levels reduces overall cancer burden.
lifestyleEndoscopic polypectomy
Prompt removal of adenomatous polyps detected during surveillance colonoscopy. Complete resection reduces progression to invasive cancer.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Diminished Msh2 Expression C6055318?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy