Disorder Due Cytochrome P450 Cyp2c9 Variant C1828420
A genetic variant affecting CYP2C9 enzyme activity influences how the body processes warfarin, NSAIDs, and other medications, potentially affecting dosing needs.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Elevated liver enzymes with standard medications
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Increased medication sensitivity
(metabolic)Fatigue after taking medications
(nervous system)Bloating after medication intake
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Alternative anticoagulation strategies
Considering direct oral anticoagulants with minimal CYP2C9 metabolism or non-vitamin K antagonist approaches when pharmacogenomic-guided warfarin dosing is impractical.
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Pharmacogenomic-guided warfarin dosing
Using CYP2C9 genotype results combined with clinical algorithms for more accurate warfarin initiation and maintenance dosing to achieve therapeutic INR safely.
Additional treatment options
NSAID alternative selection
Selecting NSAIDs with minimal CYP2C9 metabolism or considering topical formulations to minimize systemic effects and drug interaction risks.
medicationVitamin K consistency management
Maintaining consistent dietary vitamin K intake to reduce warfarin dose variability, working with nutrition services to develop appropriate meal planning strategies.
dietarySpecialist hematology consultation
Referral to hematology or anticoagulation specialists for complex cases requiring multiple CYP2C9-metabolized medications or those with recurrent adverse events.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Disorder Due Cytochrome P450 Cyp2c9 Variant C1828420?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Relling MV, Klein TE, Gammal RS, et al. Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2C9 and HLA-B genotypes and phenytoin dosing. Clin Pharmacol Ther. 2020.
Zhou SF, Liu JP, Chowbay B. Polymorphism of human cytochrome P450 2C9 and its clinical significance. Curr Drug Metab. 2009.
Tucker CE, James NM, Parker CN, et al. Impact of CYP2C9 genetic variants on warfarin maintenance dose in a diverse cohort. Clin Pharmacol Ther. 2022.
Borden BA, Kim AM, Stevens NG, et al. CYP2C9 polymorphisms and non-steroidal anti-inflammatory drug-induced gastrointestinal bleeding: a systematic review and meta-analysis. Pharmacogenomics J. 2021.
Medication Comparisons
Compare medications used to treat Disorder Due Cytochrome P450 Cyp2c9 Variant C1828420. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy