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Disorders Of Vitamin D Metabolism C5681017

Published: July 22, 2026Updated: August 20, 2026

Conditions affecting how the body processes vitamin D, which is essential for bone health. These disorders can result from genetic factors or kidney and liver dysfunction. Management includes vitamin D therapy and treating the underlying cause.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E88.9
ICD-11
5A00.0
Body system
metabolic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Bone pain

(metabolic)

Fatigue or weight changes

(metabolic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Muscle weakness

(metabolic)

Hypocalcemia

(metabolic)

Growth retardation

(metabolic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Vitamin D supplementation

Oral vitamin D3 (cholecalciferol) or vitamin D2 (ergocalciferol) supplementation to restore adequate vitamin D levels and support calcium homeostasis.

medication
3

Sun exposure optimization

Controlled sun exposure to allow cutaneous vitamin D synthesis, typically 10-30 minutes of midday sun several times weekly.

lifestyle

Additional treatment options

Calcium supplementation

Adequate dietary calcium intake through foods or supplements to complement vitamin D therapy and support bone health.

dietary

Vitamin D and calcium panel monitoring

Regular blood tests including 25-hydroxyvitamin D, calcium, and parathyroid hormone to guide therapy adjustments.

monitoring

UVB phototherapy

Controlled ultraviolet B light therapy for patients unable to achieve adequate vitamin D through oral supplementation or sun exposure.

procedure

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Disorders Of Vitamin D Metabolism C5681017?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96(7):1911-1930.

guideline2011View source →
2

Autier P, Bonhoeffer P, Sattar N, et al. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med. 2007;167(16):1730-1737.

meta_analysis2007
3

Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev. 2016;96(1):365-408.

review2016
4

Bowden SA. Disorders of Vitamin D and Calcium Homeostasis. In: Pedretti L, ed. First Aid for the USMLE Step 1 2024. McGraw-Hill Education; 2024:502-515.

other2024

Medication Comparisons

Compare medications used to treat Disorders Of Vitamin D Metabolism C5681017. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy