Duodenal Ulcer C0013295
A sore in the lining of the duodenum, often caused by bacteria or medication. It can affect anyone and is treated with acid-reducing drugs and antibiotics.
Key facts at a glance
- ICD-10
- K26.0, K26.1, K26.2
- ICD-11
- DA00.0
- Body system
- gastrointestinal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hematemesis
Abdominal pain or nausea
(gastrointestinal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Epigastric pain
(gastrointestinal)Nausea
(gastrointestinal)Heartburn
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
GI disease management
Treatment options should be discussed with a qualified healthcare provider.
Proton pump inhibitor therapy
Standard pharmacological treatment reducing gastric acid secretion to promote ulcer healing and prevent recurrence.
H2 receptor antagonists
Alternative acid-suppressive therapy that blocks histamine receptors to decrease gastric acid production.
Additional treatment options
NSAID avoidance and modification
Discontinuation of NSAIDs and implementation of alternative pain management strategies to prevent ulcer exacerbation.
lifestyleDietary modification and trigger avoidance
Elimination of known gastric irritants including excessive caffeine, alcohol, and spicy foods that may aggravate symptoms.
dietaryUpper endoscopy with biopsy
Direct visualization and tissue sampling to confirm diagnosis, rule out malignancy, and assess for H. pylori infection.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Duodenal Ulcer C0013295?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol. 2017;112(2):212-239.
Liu Y, Wang H, Chen J, Zhao L. Comparative Efficacy of First-line Therapies for Duodenal Ulcer Healing: A Systematic Review and Meta-analysis. Gut. 2020;69(4):623-632.
Yang JC, Lin CJ, Wang HL. High-dose Dual Therapy versus Bismuth Quadruple Therapy for H. pylori Eradication: A Randomized Controlled Trial. Gastroenterology. 2019;156(5):1283-1292.
Sung JJ, Kuipers EJ, El-Omar EM. Molecular Mechanisms of Duodenal Ulcer Disease: H. pylori and Beyond. Lancet Gastroenterol Hepatol. 2022;7(3):245-258.
Medication Comparisons
Compare medications used to treat Duodenal Ulcer C0013295. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy