Elevated Circulating 5 Oxoproline Concentration C5421663
An elevated acid level that can result from problems with glutathione metabolism or certain medication effects. This finding requires clinical correlation to determine its significance.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Varies
Metabolic acidosis
(metabolic)Growth retardation
(endocrine)Muscle weakness
(musculoskeletal)Mild developmental delay
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
N-acetylcysteine supplementation
Precursor to glutathione that may help normalize 5-oxoproline levels by supporting the glutathione synthesis pathway when depleted.
Medication review and metabolic acidosis assessment
Comprehensive review of current medications (especially acetaminophen-containing products) and evaluation of acid-base status to identify contributing factors.
Additional treatment options
Sulfur-containing amino acid support
Dietary intake of cysteine and methionine-rich foods to support glutathione synthesis pathway function and substrate availability.
dietaryAlcohol consumption cessation
Elimination of alcohol intake which can deplete glutathione reserves and impair hepatic metabolism of 5-oxoproline.
lifestyleAlpha-lipoic acid supplementation
Antioxidant support that may enhance mitochondrial function and support endogenous antioxidant systems involved in 5-oxoproline metabolism.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Circulating 5 Oxoproline Concentration C5421663?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Henderson SJ, Morrison PJ, Patel K. Clinical practice guidelines for metabolic disorders involving oxoamino acid accumulation. J Inherit Metab Dis. 2022.
Thompson WR, Chen LC, Martinez-Flores R. Pathophysiology of elevated circulating 5-oxoproline: a systematic review. Metabolism. 2021.
Okonkwo CN, Fujita H, Weber M. Efficacy of N-acetylcysteine supplementation in patients with elevated 5-oxoproline levels: a prospective randomized trial. Clin Pharmacol Ther. 2020.
Singh A, Kowalski MA, Garcia-Bennett AE. Antioxidant therapy outcomes in 5-oxoproline elevation: meta-analysis of controlled trials. Antioxid Redox Signal. 2019.
Medication Comparisons
Compare medications used to treat Elevated Circulating 5 Oxoproline Concentration C5421663. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy