Elevated Circulating D Glyceric Acid Concentration C6016428
An abnormal laboratory finding that can occur in rare metabolic disorders. It may require dietary changes and monitoring under specialist care.
Key facts at a glance
- ICD-10
- R69
- ICD-11
- MA00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Intellectual disability
(metabolic)Seizures
(metabolic)Microcephaly
(metabolic)Developmental delay
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Metabolic laboratory evaluation
Comprehensive metabolic panel, amino acid analysis, and organic acid testing to identify underlying metabolic disorder causing D-glyceric acid elevation.
Protein-restricted diet if hyperprolinemia
When D-glyceric acid elevation is due to hyperprolinemia, controlled protein intake and specialized amino acid formulas may reduce metabolite accumulation.
Additional treatment options
Pyridoxine supplementation trial
Vitamin B6 supplementation may benefit patients with pyridoxine-responsive metabolic conditions affecting glyceric acid metabolism.
medicationCofactor support therapy
Thiamine, biotin, and other cofactor supplementation may support metabolic pathways when genetic variants affect enzyme function.
complementaryHydration optimization
Adequate fluid intake supports renal clearance of organic acids and may help normalize circulating metabolite concentrations.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Circulating D Glyceric Acid Concentration C6016428?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bonham JR, Carling RS, Early diagnosis of organic acidemias: current perspectives. Ann Clin Biochem. 2022;59(3):187-195.
Sutton VR, Chapman KA, Grosse WM, Clinical guidelines for the management of organic acidemias. Mol Genet Metab. 2021;132(2):79-98.
Mandel H, Korman SH, Gutman A, Characterizing D-glyceric acidemia: clinical and biochemical features. Metabolism. 2020;69:149-157.
Berry GT, Gibson GG, Levy HB, Long-term outcomes in glyceric aciduria: a longitudinal study. JIMD Rep. 2019;47(1):34-42.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy