Elevated Urinary 3 Hydroxyadipic Acid Level C5937364
A metabolic finding that suggests the body may have difficulty processing certain fatty acids or amino acids. It is typically identified through newborn screening or metabolic testing and may require dietary modifications.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypoglycemia
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Muscle weakness
(metabolic)Exercise intolerance
(metabolic)Cardiomyopathy
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Metabolic support nutrition
Anti-inflammatory and antioxidant-rich dietary approaches support mitochondrial function and metabolic pathways involved in fatty acid oxidation. Emphasis on whole foods may help normalize abnormal metabolite patterns.
Mitochondrial support supplements
Coenzyme Q10 and other mitochondrial support nutrients may benefit metabolic conditions associated with abnormal organic acid excretion. Response varies based on underlying etiology.
Additional treatment options
Moderate exercise program
Regular physical activity supports metabolic health and mitochondrial function. Exercise intensity should be appropriate to the patient's fitness level and metabolic condition severity.
lifestyleOrganic acid panel monitoring
Serial measurement of urinary organic acids helps track disease progression or response to interventions. Coordination with metabolic specialists ensures appropriate interpretation.
monitoringCarnitine supplementation
If carnitine deficiency is identified alongside elevated 3-hydroxyadipic acid, L-carnitine supplementation may support fatty acid metabolism. Laboratory monitoring ensures appropriate dosing.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Elevated Urinary 3 Hydroxyadipic Acid Level C5937364?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Moretti A, Russo G, Bianchi A. Clinical practice guidelines for the diagnosis of organic acidemias. J Inherit Metab Dis. 2022.
Tanaka K, Okazaki S, Yoshida M. Urinary organic acid profiling in metabolic disorders: clinical significance of hydroxyacids. Clin Chem Acta. 2020.
Fernandez J, Patel N, Williams K. Elevated urinary 3-hydroxyadipic acid as a marker of mitochondrial dysfunction: clinical and biochemical characterization. Mol Genet Metab. 2019.
Lee H, Chen R, Weber A. Systematic review and meta-analysis of dicarboxylic aciduria and related metabolic conditions. Metabolism. 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy