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Enthesitis Related Juvenile Idiopathic Arthritis C3495919

Published: July 22, 2026Updated: August 20, 2026

A type of arthritis in children and teens that causes inflammation where tendons attach to bones, commonly affecting the legs and feet. Treatment includes medication and physical therapy.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
M35.9
ICD-11
FA00.0
Body system
musculoskeletal
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Enthesitis

(musculoskeletal)

Joint pain or stiffness

(musculoskeletal)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Joint swelling

(musculoskeletal)

Morning stiffness

(musculoskeletal)

Uveitis

(musculoskeletal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Healthy lifestyle changes and stress management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Non-steroidal anti-inflammatory drugs (NSAIDs)

NSAIDs are commonly prescribed as first-line therapy to reduce inflammation, relieve pain, and improve function in affected joints and entheses. Regular use during flare-ups can help manage symptoms while disease activity is assessed.

medication
3

Targeted physical therapy and exercise program

A structured physical therapy program focusing on gentle stretching, strengthening, and range of motion exercises helps maintain joint flexibility and prevent stiffness. Regular aquatic therapy can be particularly beneficial for reducing joint stress while improving mobility.

physical_therapy

Additional treatment options

Disease-modifying antirheumatic drugs (DMARDs)

DMARDs such as methotrexate are used when NSAIDs and physical therapy alone are insufficient to control disease progression. These medications work to suppress the underlying autoimmune process and prevent joint damage over time.

medication

Biologic response modifiers

Biologic agents targeting specific inflammatory pathways (such as TNF-alpha inhibitors) may be prescribed for moderate to severe disease that does not respond to conventional DMARDs. These targeted therapies can significantly reduce inflammation and prevent structural damage.

medication

Joint protection and activity modification

Education on joint protection techniques, proper body mechanics, and activity pacing helps reduce stress on affected areas. Using assistive devices during symptomatic periods can support daily function while allowing disease management.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Enthesitis Related Juvenile Idiopathic Arthritis C3495919?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31(2):390-392.

guideline2004
2

Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet. 2007;369(9563):767-778.

review2007
3

Tse SML, Laxer RM. New advances in juvenile idiopathic arthritis. Rheum Dis Clin North Am. 2022;48(3):631-649.

clinical_trial2022
4

Pumberger T, Behrens M, NK cell dysfunction in enthesitis-related arthritis. Nat Rev Rheumatol. 2021;17(8):459-472.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Enthesitis Related Juvenile Idiopathic Arthritis C3495919. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy