Extranodal Nasal Nk T Cell Lymphoma C0392788
A rare, aggressive cancer of natural killer cells that typically forms in the nasal area. It can spread to other tissues and often requires chemotherapy and radiation.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Epistaxis
Facial swelling
Facial pain
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Nasal obstruction
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
L-asparaginase-based chemotherapy regimens
Primary treatment combining L-asparaginase with other agents such as methotrexate, dexamethasone, and sometimes anthracyclines for newly diagnosed disease. Response rates vary based on disease extent.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Diagnostic biopsy and surgical debulking
Endoscopic biopsy for tissue diagnosis is essential. Debulking surgery may play a role in select cases with localized obstruction or tissue destruction.
Additional treatment options
Radiation therapy for localized disease
Involved-site radiotherapy may be used in combination with chemotherapy, particularly for localized nasal disease or as part of conditioning for transplant.
procedureResponse assessment and surveillance imaging
Regular PET-CT or MRI imaging to assess treatment response and detect recurrence. Endoscopic evaluation for local disease assessment.
monitoringSupportive care and nutritional support
Management of treatment side effects including pain control, nutritional supplementation, and psychosocial support. Management of paraneoplastic phenomena such as hemophagocytic syndrome.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Extranodal Nasal Nk T Cell Lymphoma C0392788?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy