Factor I Deficiency C3463916
A rare condition affecting the immune system's complement pathway. This leads to increased risk of infections and autoimmune issues.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Autoimmune hemolytic anemia
Severe angioedema with airway compromise
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent pyogenic infections
(immunologic)Chronic kidney disease
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Plasma and factor replacement therapy
Fresh frozen plasma or Factor I concentrate administration to provide functional C3b inactivator activity for infection prevention and acute management.
Antibiotic prophylaxis
Long-term prophylactic antibiotics, typically penicillin or equivalent, to prevent recurrent bacterial infections that occur due to impaired opsonization.
Additional treatment options
Immunological and infectious monitoring
Regular assessment of complement function, immunoglobulin levels, and early infection detection through patient education and scheduled laboratory evaluation.
monitoringInfection prevention practices
Implementation of hygiene measures, prompt fever evaluation protocols, and avoidance of known infectious exposures to minimize infection risk.
lifestyleNutritional support for immune function
Balanced nutritional support emphasizing adequate protein intake, vitamins, and minerals to support immune system function and general health.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Factor I Deficiency C3463916?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy