Familial Apolipoprotein C Ii Deficiency C1720779
A rare genetic disorder affecting fat metabolism, causing very high triglyceride levels in the blood. It can run in families and affect multiple relatives. Treatment involves strict dietary fat restriction and sometimes medication.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent abdominal pain
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Xanthomas
(metabolic)Hepatomegaly
(metabolic)Peripheral edema
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Very Low-Fat Diet
Strict limitation of dietary fat intake, typically to less than 10-15% of total calories, to reduce triglyceride levels. Involves elimination of simple carbohydrates and saturated fats while ensuring adequate nutrition.
Fibrate Therapy
Prescription fibrate medications that reduce triglyceride production in the liver and enhance lipoprotein lipase activity. First-line pharmacological treatment when dietary changes alone are insufficient.
Additional treatment options
Omega-3 Fatty Acid Supplementation
High-dose fish oil or prescription omega-3 fatty acid preparations to lower triglyceride levels through multiple mechanisms including reduced hepatic VLDL production.
dietaryRegular Aerobic Exercise
Consistent moderate-intensity exercise program such as walking, cycling, or swimming to improve insulin sensitivity and enhance triglyceride clearance from the bloodstream.
lifestyleLipid Profile Monitoring
Regular blood testing to track triglyceride levels and adjust treatment intensity. Includes monitoring for complications such as pancreatitis which occurs at very high triglyceride levels.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Familial Apolipoprotein C Ii Deficiency C1720779?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hegele RA, Ban MR. Inherited Lipodystrophies and Dyslipidemias in Clinical Practice. Curr Opin Lipidol. 2022.
National Lipid Association. Management of Hypertriglyceridemia: Clinical Practice Guidelines. J Clin Lipidol. 2021.
Young SG, Zechner R. Biochemistry and Pathophysiology of Apolipoprotein C-II Deficiency. Arterioscler Thromb Vasc Biol. 2020.
Gaudet D, Aigner F, Tremblay K. Efficacy of Novel Therapies in Severe Hypertriglyceridemia Associated with ApoC-II Deficiency. J Lipid Res. 2023.
Medication Comparisons
Compare medications used to treat Familial Apolipoprotein C Ii Deficiency C1720779. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy