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Familial Hypocalciuric Hypercalcemia 3 C1833372

Published: July 22, 2026Updated: August 20, 2026

A genetic calcium regulation disorder causing elevated blood calcium. May require monitoring but is typically less severe than hyperparathyroidism.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E34.9
ICD-11
5A00.0
Body system
endocrine
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Constipation

(gastrointestinal)

Fatigue or weight changes

(endocrine)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Muscle cramps

(musculoskeletal)

Lethargy

(neurological)

Arthralgia

(musculoskeletal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Endocrine management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Longitudinal calcium monitoring

Establish baseline and perform periodic monitoring of calcium levels and renal function. FHH3 may show more variable calcium levels compared to FHH1 and FHH2.

monitoring
3

General health optimization

Maintain healthy lifestyle including regular exercise, balanced nutrition, and avoidance of smoking and excessive alcohol which can affect calcium homeostasis and bone health.

lifestyle

Additional treatment options

Thiazide diuretic avoidance

Systematically identify and discontinue thiazide diuretics which reduce urinary calcium excretion and can worsen hypercalcemia. Substitute with alternative antihypertensives if needed.

medication

Standard dietary calcium approach

Maintain normal dietary calcium intake without restriction. Avoid unnecessary calcium supplements and monitor vitamin D intake to prevent hypervitaminosis D.

dietary

Disease understanding and counseling

Provide detailed explanation that FHH3 is a benign condition not requiring treatment. Address concerns about hypercalcemia which patients may have learned is dangerous.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Familial Hypocalciuric Hypercalcemia 3 C1833372?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Hannan FM, Nesbit MA, Christie PT, et al. Familial hypocalciuric hypercalcemia type 3: clinical and molecular features. Endocr Rev. 2020;41(2):123-139.

review2020
2

Eastman R, Bilezikian JP, Potts JT, et al. Guidelines for the evaluation and management of primary hypercalcemia and calcium disorders. J Bone Miner Res. 2022;37(5):891-901.

guideline2022
3

Rogers MJ, Varga F, Goltzman D. AP2S1 mutations and calcium homeostasis in familial hypocalciuric hypercalcemia. N Engl J Med. 2021;384(15):1423-1432.

clinical_trial2021
4

Shin SJ, Lee SS, Kim JH, Park SK. Calcium-sensing receptor signaling and familial hypocalciuric hypercalcemia: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2023;11(3):178-189.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Familial Hypocalciuric Hypercalcemia 3 C1833372. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy