Fanconi Anemia Complementation Group B C1845292
A rare genetic disorder impairing DNA repair that causes bone marrow failure, birth defects, and increased cancer risk. Affects children and adults. Treatment includes monitoring, transfusions, and stem cell transplant.
Key facts at a glance
- ICD-10
- D61.03
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Aplastic anemia
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Short stature
(musculoskeletal)Thumb anomalies
(musculoskeletal)Cardiac defects
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplantation
Allogeneic stem cell transplantation offers the best chance for long-term survival in FANCB-complemented patients with bone marrow failure. Matched sibling donors are preferred when available.
Growth Factor Support
Granulocyte colony-stimulating factor (G-CSF) may be used to manage severe neutropenia in FANCB patients, though responses are variable and long-term use requires careful monitoring.
Additional treatment options
Bone Marrow Evaluation
Regular bone marrow aspirates and biopsies monitor for clonal evolution, myelodysplastic changes, or leukemic transformation common in FA progression.
monitoringStress Reduction
Mind-body techniques including meditation, yoga, and relaxation exercises may help manage treatment-related stress and potentially support immune function.
complementaryNutritional Support
High-calorie, high-protein nutrition supports patients through treatment periods. Micronutrient supplementation may address specific deficiencies common in bone marrow failure states.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Fanconi Anemia Complementation Group B C1845292?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Fanconi Anemia Complementation Group B C1845292. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy