Fanconi Anemia Complementation Group C C3468041
A genetic condition affecting the body's ability to repair DNA damage. Leads to bone marrow failure, physical abnormalities, and higher cancer risk. Management involves regular monitoring and potential transplant.
Key facts at a glance
- ICD-10
- D61.03
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Pancytopenia
(hematologic)Easy bruising
(hematologic)Neutropenia
(hematologic)Hearing loss
(ear)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Hematopoietic Stem Cell Transplantation
Curative allogeneic transplantation for FANCC patients with bone marrow failure uses fludarabine-based reduced intensity conditioning to minimize toxicity while achieving engraftment.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Androgen Therapy
Synthetic androgen therapy improves blood counts in many FANCC patients, serving as first-line therapy while evaluating transplant options or as supportive care for non-transplant candidates.
Additional treatment options
Annual Cancer Screening
Comprehensive cancer surveillance including dermatologic, gynecologic, and ENT examinations detects early malignancies which are more common in FA patients.
monitoringEltrombopag Therapy
Thrombopoietin receptor agonist may be used off-label to support platelet counts in FANCC patients with thrombocytopenia, though data in FA is limited.
procedureFamily Genetic Counseling
Genetic counseling helps families understand inheritance patterns, recurrence risks, and available reproductive options including prenatal diagnosis and preimplantation genetic testing.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Fanconi Anemia Complementation Group C C3468041?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Fanconi Anemia Complementation Group C C3468041. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy