Fanconi Anemia Complementation Group E C3160739
A rare inherited condition that impairs DNA repair mechanisms, resulting in progressive bone marrow failure, physical features, and elevated cancer risk. Care includes supportive therapy and transplant evaluation.
Key facts at a glance
- ICD-10
- D61.03
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bone marrow failure
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Easy bruising
(hematologic)Thumb anomalies
(hematologic)Microcephaly
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Androgen and Corticosteroid Combination Therapy
Combined androgen therapy with low-dose corticosteroids to enhance hematologic response and reduce required androgen doses, potentially minimizing side effects while improving efficacy.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplantation (HSCT)
Curative transplant approach for patients with severe pancytopenia or transfusion dependence, utilizing reduced-intensity conditioning when appropriate to minimize toxicity.
Additional treatment options
Infection Prevention Protocols
Strict hygiene measures including hand washing, food safety practices, and avoidance of crowds to prevent infections given immunodeficiency from bone marrow dysfunction.
lifestyleEndocrine System Surveillance
Regular endocrine evaluation for growth hormone deficiency, hypothyroidism, and diabetes which occur with increased frequency in Fanconi anemia patients.
monitoringIron Chelation Therapy
Treatment with iron chelators for patients who develop iron overload from repeated transfusions, preventing organ damage from iron accumulation.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Fanconi Anemia Complementation Group E C3160739?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Fanconi Anemia Complementation Group E C3160739. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy