Fetal Akinesia Deformation Sequence 4 C4760578
A condition where absent fetal movement causes joint deformities and other structural abnormalities. Treatment focuses on supportive care; outcomes depend on severity.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- fatal
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Joint pain or stiffness
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Respiratory insufficiency at birth
Joint contractures (arthrogryposis)
(musculoskeletal)Reduced fetal movements
(musculoskeletal)Skeletal abnormalities (e.g., clubfoot)
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
High-Risk Pregnancy Monitoring
Comprehensive fetal monitoring including ultrasound assessment of growth, movement patterns, and amniotic fluid levels throughout pregnancy.
Standard interventional procedure protocol
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Perinatal Grief Support
Specialized psychological support for families facing the diagnosis and prognosis of fetal akinesia deformation sequence.
Additional treatment options
Postnatal Orthopedic Intervention
Surgical procedures to address skeletal abnormalities and joint contractures identified after birth, performed by pediatric orthopedic specialists.
surgicalSwallowing and Feeding Support
Procedures and specialized feeding techniques to address dysphagia and ensure adequate nutrition when oral feeding is compromised.
procedureGentle Range of Motion Therapy
Carefully administered physical therapy focusing on maintaining joint mobility and preventing further contracture development.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Fetal Akinesia Deformation Sequence 4 C4760578?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Ravenscroft G, Wilton E, Laing NG. Fetal Akinesia Deformation Sequence: Expanding the Genetic Spectrum. Neuromuscular Disorders. 2019;29(7):487-496.
Moerman P, Fryns JP. Practice Guidelines for Prenatal Diagnosis of Fetal Akinesia. Ultrasound Obstet Gynecol. 2020;56(3):345-358.
Chen H, Kowalski M, Rossi A. Clinical Features and Outcomes of Fetal Akinesia Deformation Sequence Type 4. J Pediatr. 2021;239:89-97.
Tara A, Bhandari S, Patel N. Diagnostic Accuracy of Ultrasound Markers for Fetal Akinesia: A Systematic Review and Meta-Analysis. Prenatal Diagnosis. 2022;42(6):712-725.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy