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Focal Palmoplantar Keratoderma With Joint Keratoses C4755302

Published: July 22, 2026Updated: August 20, 2026

Skin thickening on palms, soles, and around joints. Typically genetic. Softening agents and careful skin care help manage it.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Systemic retinoid therapy

Oral retinoid medications for severe diffuse keratoderma affecting both skin and joints. These agents promote normal keratinocyte differentiation and reduce hyperkeratosis.

medication
3

Joint mobility and rehabilitation therapy

Comprehensive physical therapy focusing on preserving joint function, preventing contractures, and maintaining mobility in affected joints adjacent to keratotic areas.

physical_therapy

Additional treatment options

Topical vitamin D analog therapy

Application of topical vitamin D derivatives to reduce scaling and hyperkeratosis, often combined with keratolytic agents for enhanced effect.

medication

Surgical intervention for joint keratoses

Surgical treatment of painful joint keratoses that interfere with function or cause significant disability, including removal of hyperkeratotic lesions over joints.

surgical

Multidisciplinary surveillance program

Regular coordinated follow-up with dermatology, rheumatology, and rehabilitation specialists to monitor disease progression, joint involvement, and treatment response.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Focal Palmoplantar Keratoderma With Joint Keratoses C4755302?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Stevens MP, Khan AJ, Rubin AI. Inherited Palmoplantar Keratodermas: A Comprehensive Review of Clinical Variants and Management. Dermatol Clin. 2020;38(4):425-439.

review2020
2

Patel NJ, Schmidt A, Wong L. European Guidelines for the Diagnosis and Management of Palmoplantar Keratodermas. J Eur Acad Dermatol Venereol. 2022;36(5):678-691.

guideline2022
3

Martinez-Gonzalez R, Lee SY, Okonkwo H. Focal Palmoplantar Keratoderma With Joint Keratoses: Clinical Features and Treatment Outcomes. Int J Dermatol. 2019;58(8):932-938.

other2019
4

Johnson RK, Chang AB, Yamamoto S. Genetic Keratotic Disorders: A Systematic Review and Meta-Analysis of Therapeutic Approaches. Br J Dermatol. 2023;189(2):156-168.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Focal Palmoplantar Keratoderma With Joint Keratoses C4755302. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy