Focal Segmental Glomerulosclerosis 5 C2750475
A hereditary kidney disease causing damage to the glomeruli, resulting in protein leakage and potential kidney function decline. It often runs in families and may lead to end-stage renal disease. Treatment includes immunosuppression and blood pressure control.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden severe flank pain
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Frothy urine
(renal)Peripheral edema
(renal)Fatigue
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive immunosuppression
Combination immunosuppressive therapy is often required for FSGS-5, typically involving corticosteroids combined with calcineurin inhibitors or alkylating agents. Treatment aims to achieve complete or partial remission of nephrotic syndrome.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Calcineurin inhibitor-based regimen
Cyclosporine or tacrolimus forms the backbone of many treatment protocols for steroid-resistant FSGS-5. These agents require therapeutic drug monitoring to maintain efficacy while minimizing toxicity.
Additional treatment options
Diuretic therapy for edema management
Loop diuretics and thiazide combinations help manage significant edema and fluid overload associated with nephrotic syndrome. Potassium and magnesium levels require careful monitoring during diuretic therapy.
medicationProtein-restricted diet
Moderate protein restriction (0.6-0.8 g/kg/day) may help reduce proteinuria and decrease kidney hyperfiltration. Protein intake should be adjusted based on nutritional status and disease progression.
dietaryPreparation for renal replacement therapy
For patients at high risk of progression to end-stage renal disease, advance care planning includes education about dialysis options and pre-emptive transplant evaluation. Vascular access planning should begin before dialysis is needed.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Focal Segmental Glomerulosclerosis 5 C2750475?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy