Focal Segmental Glomerulosclerosis 6 C3279905
A genetic variant of kidney filtering disease caused by mutations affecting the actin cytoskeleton in kidney cells. It leads to progressive scarring and proteinuria. Management focuses on slowing progression and controlling complications.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden severe flank pain
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Frothy urine
(renal)Peripheral edema
(renal)Fatigue
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aggressive multi-agent immunosuppression
FSGS-6 typically requires aggressive multi-drug immunosuppressive regimens including high-dose corticosteroids combined with calcineurin inhibitors and possibly mycophenolate mofetil. Treatment response is monitored through serial proteinuria measurements.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
RAAS blockade with optimal dosing
Maximum tolerated doses of ACE inhibitors or ARBs are used to achieve proteinuria remission and provide renoprotection. These agents are continued even after remission to prevent relapse.
Additional treatment options
Adjunctive plasma therapy
Plasmapheresis or immunoadsorption may be considered as adjunctive therapy, particularly in cases with rapid disease progression or recurrence after transplant. The goal is to remove circulating factors contributing to podocyte injury.
complementaryComprehensive lifestyle modification
A structured program addressing weight management, smoking cessation, and moderate physical activity complements medical therapy. Lifestyle changes can reduce cardiovascular risk and potentially improve treatment responsiveness.
lifestyleIntensive surveillance protocol
Frequent monitoring with weekly to biweekly assessments of proteinuria, renal function, and treatment drug levels during active disease phases. Less frequent monitoring may be appropriate during stable remission.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Focal Segmental Glomerulosclerosis 6 C3279905?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy