Focal Segmental Glomerulosclerosis 8 C4014993
A genetic subtype of kidney disease characterized by scarring of glomeruli, the kidney's blood-filtering units. It can cause nephrotic syndrome and progressive loss of kidney function. Ongoing monitoring and supportive care are essential components of management.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden severe flank pain
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Frothy urine
(renal)Peripheral edema
(renal)Fatigue
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunosuppressive therapy
Calcineurin inhibitors or alkylating agents may be employed when initial corticosteroid therapy fails to achieve remission, targeting the underlying immune-mediated glomerular injury.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Renin-angiotensin system blockade
ACE inhibitors or ARBs provide renoprotective effects by reducing proteinuria and glomerular sclerosis progression through hemodynamic and anti-fibrotic mechanisms.
Additional treatment options
Plasmapheresis
Therapeutic plasma exchange may be considered for recurrent FSGS after transplantation or severe steroid-resistant cases to remove circulating permeability factors.
procedureRenal-protective nutritional counseling
Comprehensive dietary guidance emphasizing controlled protein intake, sodium restriction, and adequate hydration supports kidney function and reduces metabolic complications.
dietarySerial proteinuria and renal function surveillance
Regular monitoring of urine protein-to-creatinine ratio, serum creatinine, and estimated glomerular filtration rate helps assess treatment response and disease progression.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Focal Segmental Glomerulosclerosis 8 C4014993?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy