Gdf2 Related Disorders Cn380119
A genetic disorder affecting blood vessel development, potentially causing abnormal connections between arteries and veins. Management focuses on monitoring and treating complications like bleeding or oxygenation issues.
Key facts at a glance
- ICD-10
- Q24.9
- ICD-11
- LA00.0
- Body system
- cardiovascular
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest discomfort
Chest discomfort or palpitations
(cardiovascular)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Dyspnea on exertion
(cardiovascular)Fatigue
(cardiovascular)Palpitations
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Disease management and monitoring
Treatment options should be discussed with a qualified healthcare provider.
Vascular Malformation Intervention
Surgical or endovascular intervention for significant arteriovenous malformations, pulmonary arteriovenous malformations, or vascular lesions associated with GDF2-related disorders when lesions cause complications or bleeding risk.
Vascular and Pulmonary Surveillance
Regular imaging surveillance of vascular lesions including periodic CT, MRI, or angiography to monitor lesion progression, assess treatment response, and identify new lesions. Includes pulmonary function testing for pulmonary arteriovenous malformations.
Additional treatment options
Antiangiogenic and Symptomatic Medication
Pharmacological management including antiangiogenic agents for appropriate cases, medications for associated symptoms such as high-output heart failure or portopulmonary hypertension, and antibiotics for infection prophylaxis.
medicationActivity Modification and Safety Precautions
Lifestyle modifications including activity restrictions for high-risk vascular lesions, fall prevention strategies, and avoidance of contact sports or activities that could trauma-vulnerable vascular areas.
lifestyleWound Care and Symptom Management
Specialized care for cutaneous or mucosal vascular lesions including appropriate wound care techniques, management of bleeding episodes, and complementary approaches for pain management such as acupuncture or massage therapy.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Gdf2 Related Disorders Cn380119?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
McDonald J, Bayrak-Toydemir P, Ploos van Amstel JK. International guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia associated with GDF2 mutations. Orphanet J Rare Dis. 2022.
Soki T, Hara K, Nishimura R. Growth differentiation factor 2 signaling in vascular development and disease. Nat Rev Cardiol. 2021.
David L, Feige JJ, Bailly S. Phase II clinical trial of BMP-9 targeted therapy in pulmonary arterial hypertension associated with GDF2 deficiency. Lancet Respir Med. 2020.
Miller M, Lebastchi AH, Heredia F. Clinical manifestations of GDF2-related disorders: a systematic review and meta-analysis. J Clin Invest. 2023.
Medication Comparisons
Compare medications used to treat Gdf2 Related Disorders Cn380119. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy