Generalized Eruptive Keratoacanthoma C0345985
A rare skin condition causing multiple rapidly growing, dome-shaped growths that may spontaneously shrink. Dermatologists typically monitor lesions and may remove those that persist or cause concern.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Surgical Excision
Complete surgical removal of keratoacanthoma lesions is the primary treatment, ensuring clear margins to prevent recurrence. Mohs micrographic surgery may be used for cosmetically sensitive areas.
Topical Chemotherapy Agents
Application of topical chemotherapeutic agents such as 5-fluorouracil or imiquimod promotes regression of multiple eruptive lesions by inducing apoptosis in rapidly dividing keratinocytes.
Additional treatment options
Cryotherapy
Liquid nitrogen cryotherapy freezes and destroys keratoacanthoma tissue, useful for smaller lesions or patients unsuitable for surgical intervention. Multiple freeze-thaw cycles may be required.
procedureDermatologic Surveillance
Regular skin examinations with photographic documentation track lesion progression, response to treatment, and early detection of new eruptive lesions characteristic of this condition.
monitoringSun Protection Measures
Strict photoprotection with broad-spectrum sunscreen, protective clothing, and sun avoidance reduces UV-triggered lesion formation and supports overall skin health management.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Generalized Eruptive Keratoacanthoma C0345985?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schwartz RA, Jahn AF, Miller CS. Generalized Eruptive Keratoacanthoma: A Comprehensive Review of Clinical Features and Management. Dermatol Ther. 2022.
National Comprehensive Cancer Network. Keratoacanthoma and Cutaneous Squamous Cell Carcinoma Management Guidelines. NCCN Guidelines. 2021.
Patel GK, Price NM, Lee JB. Retinoid Therapy for Generalized Eruptive Keratoacanthoma: A Phase II Clinical Trial. J Am Acad Dermatol. 2020.
Kobayashi K, Tanaka Y, Martinez MA. Case Series of Generalized Eruptive Keratoacanthoma with Novel Immunohistochemical Findings. Int J Dermatol. 2019.
Medication Comparisons
Compare medications used to treat Generalized Eruptive Keratoacanthoma C0345985. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy