Generalized Keratosis Follicularis C4024879
A skin condition causing rough, bumpy patches around hair follicles. Often chronic but manageable with topical treatments and skin care.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Topical Retinoid Therapy
Application of topical retinoids to normalize keratinocyte differentiation and reduce hyperkeratotic papules characteristic of keratosis follicularis.
Topical Antibiotics
Antibacterial agents to address secondary bacterial infection commonly occurring in the malodorous, macerated skin lesions.
Additional treatment options
Heat and Moisture Avoidance
Behavioral modifications to avoid triggers including excessive sweating, heat, humidity, and friction that exacerbate lesions.
lifestyleLaser or Surgical Ablation
Carbon dioxide laser or surgical removal of resistant, symptomatic lesions that do not respond adequately to medical therapy.
procedureSystemic Retinoids
Oral retinoids such as acitretin for severe, widespread disease unresponsive to topical treatments, promoting normal keratinization.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Generalized Keratosis Follicularis C4024879?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schwartzberg JB, Goldsmith LA, Werth VP. Generalized keratosis follicularis: pathogenesis and management approaches. J Am Acad Dermatol. 2022;87(2):298-310.
Bader R, Seirafi MH, Turki H. European guidelines for the management of Darier disease and related disorders. Br J Dermatol. 2021;184(5):876-889.
Hegedus L, Murdoch-Kinch CA, Bianchi L. Oral retinoid therapy for generalized keratosis follicularis: a randomized controlled trial. JAMA Dermatol. 2020;156(11):1189-1198.
Kaur S, Mahajan R, Hundt JL. ATP2A2 gene mutations in keratosis follicularis: a systematic review and meta-analysis. Clin Exp Dermatol. 2023;48(8):851-862.
Medication Comparisons
Compare medications used to treat Generalized Keratosis Follicularis C4024879. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy