Granulomatous Disease Chronic Autosomal Recessive Cytochrome B Positive Type 2 C1856245
A genetic immune disorder with defective enzyme function in white blood cells. Patients are at increased risk for serious infections and need continuous medical management.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent pneumonia
(respiratory)Skin abscess
(integumentary)Hepatic abscess
(hepatobiliary)Osteomyelitis
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic Antibiotic Therapy
Lifelong prophylactic antibiotics such as trimethoprim-sulfamethoxazole to prevent bacterial infections. This is a cornerstone of CGD management to reduce the frequency and severity of infections.
Prophylactic Antifungal Therapy
Regular antifungal prophylaxis with agents such as itraconazole to prevent Aspergillus and other fungal infections common in CGD patients.
Additional treatment options
Interferon-gamma Therapy
Subcutaneous interferon-gamma injections administered three times weekly to enhance immune function and reduce infection frequency in CGD patients.
medicationGene Therapy Investigation
Investigational gene therapy approaches being studied to correct the genetic defect in CGD, potentially offering a future curative option.
procedureHematopoietic Stem Cell Transplantation
Curative treatment approach through stem cell transplantation from a matched donor to replace defective phagocytes with functional immune cells.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Granulomatous Disease Chronic Autosomal Recessive Cytochrome B Positive Type 2 C1856245?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy