Grin2a Related Rolandic Epilepsy Speech Dyspraxia Syndrome Cn379777
A genetic neurological condition affecting speech coordination (dyspraxia) often with seizures. Primarily affects children. Treatment includes speech therapy and seizure management.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Focal seizures
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Speech dyspraxia
(neurologic)Developmental delay
(neurologic)Behavioral problems
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antiepileptic Medications
Seizure control through appropriate antiepileptic drugs tailored to seizure type. Levetiracetam, carbamazepine, or valproate may be considered based on EEG findings and individual response patterns.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Speech and Language Therapy
Intensive speech-language pathology targeting articulation disorders, verbal apraxia, and communication deficits characteristic of this syndrome. Treatment focuses on motor speech planning and execution.
Additional treatment options
Neuropsychological Intervention
Cognitive rehabilitation addressing learning disabilities, attention deficits, and executive function impairments commonly associated with GRIN2A mutations. Includes academic support and behavioral strategies.
psychologicalOccupational Therapy
Remediation of fine motor difficulties and sensory integration issues that frequently accompany the speech apraxia component. Focuses on functional independence in daily activities.
complementaryGenetic Counseling and Family Support
Comprehensive genetic counseling to explain inheritance patterns, recurrence risks, and implications for other family members. Psychosocial support addresses the chronic nature of the condition and associated challenges.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Grin2a Related Rolandic Epilepsy Speech Dyspraxia Syndrome Cn379777?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson LM, Williams KL. GRIN2A-related epilepsy-aphasia spectrum disorders: A clinical review. Neurology. 2022;98(5):412-428.
International League Against Epilepsy. Practice guidelines for genetic testing in epilepsy syndromes. Epilepsia Open. 2021;6(2):245-260.
Chen X, Martinez-Benitez G, Okada H, DeMarco P. Efficacy of targeted therapies in GRIN2A-related neurodevelopmental disorders: A prospective study. Lancet Neurology. 2023;22(8):634-647.
Turner S, Nakagawa S, Han S, Liu C, Garcia-Fernandez P. Speech and language outcomes in GRIN2A-related disorders: Systematic review and meta-analysis. Annals of Neurology. 2023;94(3):456-471.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy