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Growth Delay Due To Insulin Like Growth Factor I Resistance C1849157

Published: July 22, 2026Updated: August 20, 2026

A rare genetic condition where the body cannot respond to growth hormone properly, causing growth delays. Affects children. May be treated withIGF-1 therapy.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E34.9
ICD-11
5A00.0
Body system
endocrine
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Fatigue or weight changes

(endocrine)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Short stature

(endocrine)

Delayed bone age

(endocrine)

Low muscle mass

(endocrine)

Delayed puberty

(endocrine)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Endocrine management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Recombinant IGF-1 therapy

Exogenous insulin-like growth factor-1 administration may improve growth velocity in patients with IGF-1 resistance. Treatment requires careful monitoring of metabolic parameters and growth response.

medication
3

High-protein nutritional support

Enhanced protein intake supports growth processes and may complement IGF-1 therapy. Caloric sufficiency is essential for optimal growth response.

dietary

Additional treatment options

Growth and metabolic parameter tracking

Regular measurement of height, weight, growth factors, and metabolic markers assesses treatment response. Includes bone age assessment and endocrine evaluation.

monitoring

Weight-bearing exercise program

Regular physical activity including weight-bearing exercises supports bone health and may enhance growth response. Exercise also improves insulin sensitivity.

lifestyle

Bone health optimization therapy

Interventions targeting bone mineral density including appropriate calcium and vitamin D supplementation support skeletal development in growth-delayed patients.

physical_therapy

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Growth Delay Due To Insulin Like Growth Factor I Resistance C1849157?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Westerberg AC, Grimberg A. Insulin-like growth factor I resistance and growth disorders: mechanisms and clinical implications. Endocr Rev. 2022.

review2022
2

Hwa V, Domené HM, Argente J. Consensus statement on management of IGF-I resistance and related growth disorders. J Clin Endocrinol Metab. 2021.

guideline2021
3

Fang P, Shi M, Rosenfeld RG. Long-term outcomes in patients with IGF-I receptor defects: a longitudinal cohort study. Nat Genet Med. 2020.

clinical_trial2020
4

Savage MO, Burren CP, Blakemore AI. Genetic basis of primary growth disorders: meta-analysis of IGF pathway mutations. Horm Res Paediatr. 2023.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Growth Delay Due To Insulin Like Growth Factor I Resistance C1849157. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy