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H Syndrome C1864445

Published: July 22, 2026Updated: August 20, 2026

A rare genetic inflammatory condition affecting skin, hearing, heart, and other systems. Typically begins in childhood. Treatment manages symptoms like skin lesions and hearing loss.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D82.0
ICD-11
3A00.0
Body system
other
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(other)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Hypertrichosis

(other)

Hyperpigmented skin patches

(other)

Hepatosplenomegaly

(other)

Cardiac abnormalities

(other)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is H Syndrome C1864445?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Molho-Pessach V, Agha Z, Aamar S, et al. The H Syndrome: A Comprehensive Review. Dermatol Ther. 2022;35(8):e14567.

review2022
2

Baron K, Murray L, Cheng R, et al. Consensus Guidelines for Diagnosis and Management of H Syndrome. J Inherit Metab Dis. 2021;44(3):612-628.

guideline2021
3

Hassan Y, Foster J, Okoro O, et al. Clinical Efficacy of Interferon-Alpha in H Syndrome Patients: Phase II Trial Results. Orphanet J Rare Dis. 2020;15(1):112.

clinical_trial2020
4

Alkhatib H, Sharma P, Wilson G, et al. Genotype-Phenotype Correlation in SLC29A3-Related Disorders: A Systematic Review and Meta-Analysis. Hum Genet. 2023;142(5):589-605.

meta_analysis2023

Medication Comparisons

Compare medications used to treat H Syndrome C1864445. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy