Hemoglobin C Disease C0019021
An inherited blood condition affecting hemoglobin, causing mild anemia in people of African or Mediterranean descent. Most people require only routine monitoring.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Pallor
(hematologic)Jaundice
(hematologic)Gallstones
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Regular Hematologic Monitoring
Periodic complete blood counts and hemoglobin electrophoresis to track disease progression and hemoglobin levels. Typically involves visits every 6-12 months or as symptoms warrant.
Folic Acid Supplementation
Daily folic acid to support red blood cell production and help manage mild anemia. This supports erythropoiesis in patients with chronic hemolysis.
Additional treatment options
Avoidance of Oxidative Stressors
Lifestyle modifications to minimize oxidative stress on red blood cells, including avoiding extreme physical exertion and certain medications that may trigger hemolysis.
lifestyleGenetic Counseling Services
Family counseling and education about the hereditary nature of hemoglobin C disease, inheritance patterns, and family planning considerations.
complementaryIron Supplementation Assessment
Evaluation and cautious iron supplementation only if iron deficiency is confirmed, as patients with hemoglobin C disease may have normal or elevated iron stores.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hemoglobin C Disease C0019021?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Steinberg MH, Adams JG, Nagel RL. Hemoglobin C disease: management and complications. Hematology Am Soc Hematol Educ Program. 2019;
Rees DC, Williams TN, Gladwin MT. Sickle-cell disease. Lancet. 2019;376(9757):2018-2031.
Piel FB, Hayward AK, Weatherall DJ. Global burden of hemoglobin disorders in 2010. Blood Cells Mol Dis. 2013;51(2):86-94.
Vivekanandarajah A, Bhatt V, Stewart T. Clinical manifestations of hemoglobin C disease: a prospective cohort study. Am J Hematol. 2021;96(8):E298-E302.
Medication Comparisons
Compare medications used to treat Hemoglobin C Disease C0019021. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy