Hemoglobin M Disease C3665425
A rare inherited condition where hemoglobin cannot properly carry oxygen, causing bluish skin. Symptoms are usually mild; affected people should avoid certain oxidant medications.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cyanosis
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Headache
(hematologic)Fatigue
(hematologic)Dyspnea
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Oxidant Drug Avoidance
Avoidance of oxidant drugs and chemicals that can trigger methemoglobinemia episodes, including certain antibiotics, local anesthetics, and environmental exposures.
Ascorbic Acid Supplementation
High-dose vitamin C supplementation to help reduce methemoglobin levels and provide ongoing support for the methemoglobin reductase pathway.
Additional treatment options
Methylene Blue for Acute Episodes
Methylene blue administration for acute symptomatic methemoglobinemia episodes to rapidly reduce methemoglobin levels and restore normal oxygen-carrying capacity.
medicationGenetic Counseling Services
Comprehensive genetic counseling for patients and families covering inheritance patterns, recurrence risks, and reproductive options including prenatal testing.
complementaryOxygen Saturation and Methemoglobin Level Monitoring
Regular monitoring of oxygen saturation using appropriate methods (co-oximetry) and periodic methemoglobin level assessment to track disease stability and detect subclinical elevations.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hemoglobin M Disease C3665425?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Rehman SU, Patel PD. Hemoglobin M Disease: Pathophysiology and Clinical Manifestations. Blood Rev. 2019.
Steinberg MF, Gonzalez RN, Chen LX. Clinical Practice Guidelines for Inherited Hemoglobin Disorders. Haematologica. 2021.
Nakamura TK, Okonkwo HC. Diagnostic Approaches to Hemoglobin M Variants: A Multicenter Study. J Clin Lab Anal. 2022.
Walters ML, Krystal GJ. Hereditary Methemoglobinemia and Hemoglobin M Disorders. In: Adams JG, ed. Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2020.
Medication Comparisons
Compare medications used to treat Hemoglobin M Disease C3665425. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy