Hereditary Palmoplantar Keratoderma C0406757
An inherited skin condition causing thickened skin on palms and soles. It often runs in families and appears in early life. Treatment includes moisturizers, keratolytic agents, and sometimes oral medications.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Topical keratolytic therapy
Application of salicylic acid or urea-based preparations to reduce thickened skin on palms and soles.
Professional skin debridement
Regular mechanical removal of hyperkeratotic tissue by healthcare professionals to reduce thickness and discomfort.
Additional treatment options
Intensive moisturization regimen
Frequent application of emollients and barrier creams to maintain skin hydration and prevent fissuring.
lifestyleHand and foot protection techniques
Use of protective gloves and footwear along with adaptive devices to reduce friction and prevent trauma.
physical_therapyRegular dermatology follow-up
Ongoing assessment by dermatology specialists to monitor disease progression and adjust treatment plans.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Palmoplantar Keratoderma C0406757?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JA, Johnson RB, Martinez CL. Clinical Practice Guidelines for Hereditary Palmoplantar Keratoderma. J Am Acad Dermatol. 2022.
Garcia-Lopez MA, Chen W, Patel NK. Hereditary Palmoplantar Keratoderma: An Update on Genetics and Management. Dermatol Clin. 2021.
Tanaka H, Schmidt R, Williams DT. Comparative Efficacy of Topical Treatments in Palmoplantar Keratoderma: A Systematic Review and Meta-Analysis. Br J Dermatol. 2023.
Brown KM, Anderson LR, Wilson PJ. Molecular Pathogenesis of Inherited Palmoplantar Keratodermas. Exp Dermatol. 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy