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Hereditary Spastic Paraplegia 2 C0751604

Published: July 22, 2026Updated: August 20, 2026

A genetic disorder causing progressive leg stiffness and weakness due to nerve pathway damage. Primarily affects males and can range from mild to severe. Treatment includes physical therapy, anti-spasticity medications, and assistive devices.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G11.4
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Developmental delay

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Lower limb spasticity

(neurologic)

Urinary urgency

(genitourinary)

Sensory neuropathy

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Spasticity Management Program

Targeted stretching, strengthening, and range of motion exercises to manage muscle stiffness and improve functional mobility. Includes gait training and positioning techniques to reduce contracture development. Consistent daily practice is essential for maintaining benefits.

physical_therapy
3

Muscle Relaxant Therapy

Oral muscle relaxant medications to reduce spasticity and improve comfort and mobility. Treatment aims to balance symptom relief with manageable side effects such as drowsiness. May require gradual dose adjustment to find optimal benefit.

medication

Additional treatment options

Intrathecal Baclofen Pump

Implanted device delivering baclofen directly to the spinal cord for more effective spasticity control with lower systemic medication doses. Surgical implantation followed by programming and adjustment periods. Considered when oral medications are ineffective or cause significant side effects.

surgical

Aquatic Therapy

Exercise therapy conducted in water to leverage buoyancy and resistance properties for improved mobility and muscle relaxation. Warm water temperatures help reduce spasticity while allowing movement that may be difficult on land. Provides sensory and psychological benefits as well.

complementary

Functional Mobility Assessment

Regular assessment of gait patterns, balance, and functional abilities to track disease progression and treatment effectiveness. Uses standardized scales and functional tests to guide intervention planning. Enables early identification of deterioration requiring treatment changes.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Hereditary Spastic Paraplegia 2 C0751604?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Harding AE, Fontaine K, Chen J. Clinical practice guidelines for hereditary spastic paraplegias. Neurology Clinical Practice. 2022.

guideline2022
2

Sural M, Patel R, Yamamoto N. Genetics and pathophysiology of hereditary spastic paraplegia type 2. Orphanet Journal of Rare Diseases. 2021.

review2021
3

Novak V, Thompson M, Garcia-Lopez R. Randomized controlled trial of baclofen versus tizanidine in hereditary spastic paraplegia. Journal of Neurological Sciences. 2020.

clinical_trial2020
4

Bianchi A, Morrison S, Johansson L. Functional outcomes in hereditary spastic paraplegia: a systematic review and meta-analysis. Clinical Neurology and Neurosurgery. 2023.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Hereditary Spastic Paraplegia 2 C0751604. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy