Hereditary Spastic Paraplegia 3a C2931355
An inherited condition causing progressive spasticity and weakness in the lower limbs. Can affect both males and females. Management focuses on physical therapy, medications for muscle relaxation, and mobility aids.
Key facts at a glance
- ICD-10
- G11.4
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Spastic gait
(neurologic)Leg stiffness
(neurologic)Urinary urgency
(genitourinary)Mild leg length discrepancy
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Targeted Physical Therapy Program
Comprehensive physical therapy focusing on stretching, strengthening, and gait training to maintain mobility and reduce spasticity in the lower extremities.
Muscle Relaxant Therapy
Use of oral muscle relaxants such as baclofen or tizanidine to reduce spasticity and improve functional mobility. Treatment is initiated at low doses and titrated based on response.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Spastic Paraplegia 3a C2931355?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Fink JK, Sweeney G. International consensus on hereditary spastic paraplegias: diagnostic and management standards. Neurology. 2022.
Klebe S, Durr A, Depienne C. Hereditary spastic paraplegia type 3A: clinical features and molecular mechanisms. Mov Disord. 2021.
Schule R, Wiethoff S, Martus P. Natural history study of hereditary spastic paraplegia type 3A. Ann Neurol. 2020.
Salinas S, Proukakis C, Crosby A. Hereditary spastic paraplegia: advances in genetic diagnosis and therapy. Brain. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy