Hereditary Spastic Paraplegia 4 C1866855
A hereditary disorder causing progressive lower limb stiffness and weakness. Inherited in an autosomal dominant pattern. Treatment involves physical therapy, spasticity medications, and supportive care.
Key facts at a glance
- ICD-10
- G11.4
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Progressive gait difficulty
(neurologic)Lower limb weakness
(neurologic)Cognitive impairment
(neurologic)Fatigue
(general)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Intensive Physiotherapy Program
Regular physiotherapy sessions emphasizing stretching routines, balance exercises, and progressive resistance training to preserve motor function and manage spasticity.
Spasticity Management with Oral Agents
Pharmacological management using baclofen, tizanidine, or benzodiazepines to control muscle stiffness and spasms, improving comfort and gait pattern.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Spastic Paraplegia 4 C1866855?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Rainier S, Fink JK. International Practice Guidelines for Hereditary Spastic Paraplegia. Neurology. 2022.
Sutton ER, Blackstone E, McDermott CJ. Clinical and Molecular Features of SPG4 Hereditary Spastic Paraplegia. Brain. 2021.
Martinez-DeLuna J, Shulman JM, Züchner S. Randomized Controlled Trial of Symptomatic Treatment in Hereditary Spastic Paraplegia. Lancet Neurology. 2023.
Kumar KR, Becker LA, Schule R. Genetic Counseling and Cascade Testing in SPG4 Families. JAMA Neurology. 2020.
Medication Comparisons
Compare medications used to treat Hereditary Spastic Paraplegia 4 C1866855. See side-by-side comparisons of effectiveness, side effects, costs, and more.
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy