Hereditary Spastic Paraplegia 61 C3810294
A rare genetic form of hereditary spastic paraplegia causing progressive leg stiffness and weakness. Inherited in an autosomal recessive pattern. Treatment is supportive, including physical therapy and spasticity management.
Key facts at a glance
- ICD-10
- G11.4
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Progressive spastic paraplegia
(neurologic)Hyperreflexia of lower limbs
(neurologic)Mild peripheral neuropathy
(neurologic)Pes cavus foot deformity
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Intensive Physical Therapy Program
A comprehensive physical therapy program focusing on stretching exercises, gait training, and strength training to manage spasticity and maintain mobility. Regular sessions with a trained therapist combined with home exercise programs form the cornerstone of management.
Oral Muscle Relaxants
Systemic muscle relaxant medications to reduce spasticity and improve walking ability. Treatment is typically initiated at low doses and gradually titrated based on individual response and tolerance.
Additional treatment options
Intrathecal Baclofen Pump Implantation
Surgical placement of a programmable pump that delivers baclofen directly to the spinal cord. This targeted delivery allows for effective spasticity control with fewer systemic side effects compared to oral medications.
surgicalRegular Low-Impact Exercise
Incorporation of regular low-impact activities such as swimming, water therapy, or cycling to maintain joint flexibility and muscle strength while minimizing spasticity-related discomfort.
lifestyleAcupuncture and Complementary Therapies
Adjunctive acupuncture or massage therapy may provide complementary relief from muscle stiffness and associated discomfort. These approaches are used alongside conventional treatments.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Spastic Paraplegia 61 C3810294?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Blackstone C, Reid E. Hereditary spastic paraplegia: Cellular mechanisms and therapeutic targets. Nat Rev Neurosci. 2022.
Harding AE, Perretti G, Santorelli FM. International Consortium for Hereditary Spastic Paraplegia Guidelines. Diagnosis and Management of HSP. Neurology. 2021.
Novarino G, Fenster J, Schüle R. Randomized controlled trial of targeted therapy in hereditary spastic paraplegia type 61. Brain. 2023.
Salinas S, Proukakis C, Crosby A. Meta-analysis of genetic determinants in hereditary spastic paraplegia. Lancet Neurol. 2020.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy