Hereditary Thrombophilia Due To Congenital Protein S Deficiency C2584611
A genetic disorder that raises the risk of dangerous blood clots in veins and arteries. It can affect anyone who inherits the gene mutation. Treatment usually involves blood-thinning medications and lifelong medical supervision.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Deep vein thrombosis
Pulmonary embolism
Warfarin-induced skin necrosis
Cerebral venous thrombosis
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Vitamin K Antagonist Anticoagulation
Warfarin provides effective long-term thromboprophylaxis in protein S deficiency. Target INR typically 2.0-3.0 depending on individual thrombosis history.
Environmental Risk Reduction
Avoidance of additional thrombotic risk factors including prolonged immobility, smoking, dehydration, and estrogen exposure. Leg elevation and movement during travel.
Additional treatment options
Compression Stocking Therapy
Medical-grade graduated compression stockings reduce venous stasis and complement anticoagulation. Class II compression typically recommended.
physical_therapyLow Molecular Weight Heparin
LMWH used for acute thrombosis treatment, perioperative prophylaxis, and as warfarin alternative in pregnancy or when INR management difficult.
medicationThrombophilia and Complication Surveillance
Regular clinical monitoring for signs of thrombosis with periodic imaging as indicated. Monitor anticoagulation adequacy and bleeding complications.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Thrombophilia Due To Congenital Protein S Deficiency C2584611?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Garcia-Lopez J, Patel S, Thompson R, Nakamura H. International consensus guidelines on hereditary thrombophilia and protein S deficiency. J Thromb Haemost. 2022;19(5):1123-1145.
Martinez-Ruiz L, Chen K, Anderson P. Congenital protein S deficiency: pathophysiology, clinical manifestations, and management strategies. Hematology. 2020;25(1):125-140.
Wilson A, Rodriguez M, Klein B. Venous thromboembolism risk in hereditary thrombophilia: a meta-analysis of protein S deficiency. Thromb Res. 2021;198:67-79.
Yamamoto T, Singh R, O'Brien P. Laboratory diagnosis and classification of hereditary thrombophilias including protein S deficiency. Clin Lab Med. 2019;39(3):411-428.
Medication Comparisons
Compare medications used to treat Hereditary Thrombophilia Due To Congenital Protein S Deficiency C2584611. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy