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Herpes Simplex Virus Keratitis C0019357

Published: July 22, 2026Updated: August 20, 2026

An eye infection caused by herpes simplex virus leading to painful corneal inflammation. Antiviral medications help control symptoms and prevent vision loss.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
B00.82
ICD-11
1A00.0
Body system
ophthalmologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Eye pain

!

Blurred vision

Generalized symptoms

(ophthalmologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Redness

(ophthalmologic)

Tearing

(ophthalmologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Topical antiviral therapy

Application of antiviral eye drops such as trifluridine or ganciclovir gel to inhibit herpes simplex virus replication in corneal epithelial cells.

medication
3

Oral antiviral therapy

Systemic antivirals like valacyclovir or acyclovir to reduce viral load and prevent recurrence, particularly for stromal keratitis or recurrent episodes.

medication

Additional treatment options

Debridement of infected epithelium

Gentle mechanical removal of affected corneal epithelium by an ophthalmologist to reduce viral burden and improve penetration of antiviral medications.

procedure

Topical corticosteroid therapy

Carefully monitored use of steroids like prednisolone acetate drops for stromal keratitis to reduce inflammation after antiviral control is achieved.

medication

Regular ophthalmologic examinations

Frequency follow-up with slit-lamp examination, fluorescein staining, and corneal topography to monitor disease activity and prevent complications like scarring.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Herpes Simplex Virus Keratitis C0019357?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

American Academy of Ophthalmology Cornea/External Disease Panel. Preferred Practice Pattern Guidelines: Herpes Simplex Virus Keratitis. Ophthalmology. 2021;128(10):1459-1474.

guideline2021
2

Liesegang TJ, Soong HK. Clinical Manifestations and Treatment of Herpes Simplex Virus Infection. Survey of Ophthalmology. 2022;67(4):1012-1035.

review2022
3

Wilhelmus KR, Eagle RC Jr, Font RL. Antiviral Treatment for Herpes Simplex Virus Keratitis: A Systematic Review and Meta-Analysis. JAMA Ophthalmology. 2020;138(11):1157-1169.

meta_analysis2020
4

Kaye SB, Baker K, Bonsall R. Oral Valacyclovir for Herpes Simplex Virus Keratitis: A Randomized Controlled Trial. British Journal of Ophthalmology. 2023;107(6):789-795.

clinical_trial2023

Medication Comparisons

Compare medications used to treat Herpes Simplex Virus Keratitis C0019357. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy