High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12 C2675071
A genetic region influencing HDL cholesterol levels in some individuals. This trait is inherited and interacts with lifestyle factors. Maintaining a healthy weight and diet is advised.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
High HDL cholesterol concentration
(metabolic)Mild familial hyperalphalipoproteinemia
(metabolic)Increased HDL‑associated apolipoprotein A‑I levels
(metabolic)Rare skin lesion (HDL‑rich papular xanthoma)
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Alcohol Moderation
Limiting alcohol intake to moderate levels, as excessive alcohol can negatively impact lipid profiles while moderate intake may have some HDL benefits.
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Plant Sterol-Enriched Foods
Incorporation of plant sterol or stanol fortified foods such as spreads and yogurts, which compete with cholesterol absorption and support healthy HDL levels.
Additional treatment options
High-Intensity Interval Training
Brief bursts of intense exercise alternating with recovery periods, shown to be particularly effective at improving HDL function and cardiovascular fitness.
physical_therapyGenetic Counseling and Testing
Family screening and genetic counseling to understand inheritance patterns and identify at-risk relatives who may benefit from early intervention.
monitoringFibrate Therapy
Fibrate medications may be considered in consultation with a specialist when lifestyle interventions are insufficient to achieve target HDL levels.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12 C2675071?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Circulation. 2019.
Rader DJ, Hovingh GK. HDL and cardiovascular disease. Lancet. 2014.
Briel M, Ferreira-Gonzalez I, You JJ, et al. Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis. BMJ. 2009.
Tall AR, Rader DJ. Trials and Tribulations of CETP Inhibitors. Circ Res. 2018.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy