High Grade B Cell Lymphoma C0456863
An aggressive cancer of the lymphatic system that grows and spreads quickly. Treatment typically involves chemotherapy and sometimes targeted therapies or stem cell transplant.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fever
Lymphadenopathy
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Night sweats
(hematologic)Weight loss
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
R-CHOP chemotherapy regimen
First-line immunochemotherapy combining rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone. This regimen targets cancer cells through multiple mechanisms and is standard for aggressive B-cell lymphomas.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Central nervous system prophylaxis
Intrathecal chemotherapy or systemic high-dose methotrexate to prevent lymphomatous involvement of the central nervous system, which occurs in a subset of high-grade lymphoma cases.
Additional treatment options
Second-line salvage chemotherapy
Intensive chemotherapy regimens such as GDP, ICE, or DHAP for patients who relapse or don't respond to initial therapy, prior to consideration of stem cell transplant.
medicationAutologous stem cell transplantation
High-dose chemotherapy followed by reinfusion of patient's own stem cells to achieve durable remission in eligible patients with chemo-sensitive disease.
procedureResponse assessment and surveillance
Regular imaging studies and periodic surveillance to assess treatment response and detect relapse early, typically including PET-CT scans during and after therapy.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is High Grade B Cell Lymphoma C0456863?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy