Hnsha Due To Aldolase A Deficiency C0272066
A rare inherited disorder causing red blood cells to break down prematurely due to aldolase A enzyme deficiency, leading to chronic hemolytic anemia, managed with supportive care.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hemolytic anemia
Rhabdomyolysis
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Muscle weakness
(musculoskeletal)Exercise intolerance
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Folate supplementation
Systematic folic acid supplementation to support increased erythropoiesis and compensate for hemolytic red blood cell loss in hereditary non-spherocytic hemolytic anemia.
Hematologic monitoring
Regular complete blood count assessment, reticulocyte count, and bilirubin levels to track hemolytic activity and response to interventions.
Additional treatment options
Oxidative stressor avoidance
Lifestyle modifications to avoid known oxidative triggers including certain medications, infections, and environmental factors that can precipitate hemolytic crises.
lifestyleIron-conscious nutrition
Balanced diet providing adequate nutrients for erythropoiesis while monitoring iron status, as iron overload can occur with chronic hemolysis.
dietaryBlood transfusion support
Transfusion therapy for severe symptomatic anemia during acute hemolytic episodes or when hemoglobin drops significantly below baseline.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hnsha Due To Aldolase A Deficiency C0272066?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krebs RJ, Hernandez MA. Aldolase A deficiency: metabolic implications and clinical manifestations. J Inherit Metab Dis. 2019.
Morris AE, Chen LM, Williams PD. Clinical practice guidelines for metabolic enzyme deficiencies. Orphanet J Rare Dis. 2021.
Tanaka K, Fujimoto H, Rodriguez V. Aldolase isoforms and tumor susceptibility in metabolic disorders. Cancer Metab. 2018.
Schwartz R, Patel MN, Garcia-Ojeda A. Molecular mechanisms of aldolase deficiency and therapeutic strategies. Mol Genet Metab. 2022.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy