Holoprosencephaly 4 C1840528
A severe brain malformation in which the forebrain fails to properly divide. It is linked to particular genetic factors and presents significant developmental challenges.
Key facts at a glance
- ICD-10
- Q04.2
- ICD-11
- LA00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Developmental delay
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cleft lip/palate
(neurologic)Pituitary dysfunction
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Developmental milestone tracking
Systematic assessment of cognitive, motor, and social development at regular intervals using standardized tools. Allows for early identification of delays requiring intervention and measures progress over time.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Spasticity management
Pharmacological treatment of increased muscle tone using oral muscle relaxants or intrathecal baclofen pumps. Reduces discomfort, improves positioning, and facilitates hygiene care.
Additional treatment options
Aquatic therapy program
Water-based therapy utilizing buoyancy to support movement and reduce joint stress. Improves range of motion, muscle strength, and provides sensory input in a low-gravity environment.
physical_therapySensory integration therapy
Occupational therapy focused on processing and responding to sensory information. Addresses tactile defensiveness, vestibular issues, and helps develop appropriate responses to environmental stimuli.
complementaryOrthopedic intervention
Surgical management of skeletal complications including hip subluxation, scoliosis, and contractures. May involve soft tissue releases, osteotomies, or spinal fusion depending on specific needs.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Holoprosencephaly 4 C1840528?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Holoprosencephaly 4 C1840528. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy