Hyper Ige Recurrent Infection Syndrome 4a Autosomal Dominant C5676920
A rare immune disorder causing dangerously high antibody levels, recurrent skin and lung infections, and bone problems. It is inherited from a parent. Treatment focuses on preventing infections and managing complications.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pneumonia with pneumatocele formation
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent staphylococcal skin abscesses ('cold abscesses')
(skin)Eczema with secondary infections
(skin)Retained primary teeth (delayed eruption)
(dental)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic Antibiotic Therapy
Long-term antibiotic regimens to prevent recurrent bacterial infections, particularly respiratory and skin infections common in Hyper-IgE syndrome.
Antifungal Prophylaxis
Antifungal medications to prevent recurrent Candida and other fungal infections affecting skin, nails, and mucous membranes in these immunocompromised patients.
Additional treatment options
Infection Prevention Practices
Meticulous hygiene measures including regular skin care, dental hygiene, avoiding contact with sick individuals, and environmental precautions to reduce infection risk.
lifestyleIncision and Drainage of Skin Abscesses
Prompt surgical management of cutaneous abscesses with drainage and appropriate cultures to guide targeted antimicrobial therapy.
procedureIgE Level and Infection Surveillance
Regular monitoring of serum IgE levels and comprehensive infection workup with each febrile episode to guide therapeutic decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Hyper Ige Recurrent Infection Syndrome 4a Autosomal Dominant C5676920?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Hyper Ige Recurrent Infection Syndrome 4a Autosomal Dominant C5676920. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy