Hyperinsulinemic Hypoglycemia With Polycystic Kidney Disease Cn377840
A rare condition combining low blood sugar from excess insulin with polycystic kidney disease. It affects multiple organs and requires careful monitoring. Treatment includes dietary management and kidney function surveillance.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Diazoxide
Potassium channel activator that suppresses insulin secretion from pancreatic beta cells, helping manage hyperinsulinemic hypoglycemia by preventing inappropriate insulin release.
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Complex Carbohydrate Diet with Frequent Feeding
Structured feeding schedule with slow-digesting carbohydrates maintains stable glucose levels and reduces hypoglycemic episodes throughout the day.
Additional treatment options
Pancreatectomy
Surgical removal of abnormal pancreatic tissue may be considered in focal disease or refractory cases unresponsive to medical management.
procedureContinuous Glucose Monitoring
Real-time glucose tracking enables early detection of hypoglycemic episodes and guides dietary and medication adjustments for optimal metabolic control.
monitoringEverolimus
mTOR inhibitor may be considered off-label for refractory hyperinsulinism, particularly in patients with associated renal involvement, as it affects pancreatic beta cell proliferation.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Hyperinsulinemic Hypoglycemia With Polycystic Kidney Disease Cn377840?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy