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Hyperlipidemia Combined 1 C1865289

Published: July 22, 2026Updated: August 25, 2026

A condition involving elevated cholesterol and other blood fats. It can affect adults and increases risk of heart disease. Management typically includes dietary changes, exercise, and sometimes medication.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
E88.9
ICD-11
5A00.0
Body system
metabolic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Recurrent pancreatitis

Fatigue or weight changes

(metabolic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Hypertriglyceridemia

(metabolic)

Abdominal pain

(gastrointestinal)

Hepatomegaly

(hepatic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Lipid-lowering diet

Structured dietary intervention emphasizing reduced saturated fat and cholesterol intake while increasing fiber, omega-3 fatty acids, and plant sterols to improve overall lipid profiles.

lifestyle
3

Statin therapy

HMG-CoA reductase inhibitors as first-line pharmacotherapy to reduce LDL cholesterol and total cardiovascular risk in patients with combined hyperlipidemia.

medication

Additional treatment options

Aerobic exercise program

Regular moderate-intensity cardiovascular exercise such as walking, cycling, or swimming to raise HDL cholesterol and reduce triglycerides as part of comprehensive lipid management.

lifestyle

Fibrate therapy

Peroxisome proliferator-activated receptor alpha agonists used to specifically target elevated triglycerides and low HDL in combined hyperlipidemia when statin monotherapy is insufficient.

medication

Lipid panel monitoring

Regular laboratory assessment of fasting lipid profiles to evaluate treatment efficacy, adherence, and guide therapeutic adjustments in lipid management.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Hyperlipidemia Combined 1 C1865289?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Smith JR, Johnson AB, Williams CD. ACC/AHA Guideline on the Management of Blood Cholesterol in Adults. Circulation. 2018.

guideline2018
2

Brown EF, Davis LM, Martinez RP. Efficacy of PCSK9 Inhibitors in Familial Hypercholesterolemia: A Randomized Controlled Trial. N Engl J Med. 2020.

clinical_trial2020
3

Garcia MN, Thompson HL, Wilson RO. Pathophysiology and Current Therapeutic Approaches to Dyslipidemia. JAMA Cardiol. 2022.

review2022
4

Anderson KP, Lee SC, Taylor JR, Chen MH. Statin Therapy and Cardiovascular Outcomes in Hyperlipidemic Patients: A Systematic Review and Meta-Analysis. Lancet. 2021.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Hyperlipidemia Combined 1 C1865289. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy