Hyperparathyroidism 3 C1864729
A genetic form of hyperparathyroidism where multiple parathyroid glands are overactive. It runs in families and treatment depends on severity, potentially including surgery to remove abnormal tissue.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypercalcemia
(endocrine)Polyuria and polydipsia
(endocrine)Nephrocalcinosis
(endocrine)Osteitis fibrosa cystica
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Targeted parathyroid surgery
Minimally invasive parathyroidectomy with intraoperative PTH monitoring provides definitive treatment by removing the affected gland(s). This approach minimizes surgical trauma while ensuring biochemical cure based on real-time PTH level changes.
Bisphosphonate therapy
Bisphosphonates help reduce bone resorption and lower serum calcium levels in hyperparathyroidism. They are particularly beneficial for patients with decreased bone mineral density who are awaiting or unable to undergo surgery.
Additional treatment options
Calcimimetic agents
Cinacalcet or etelcalcetide lower PTH and calcium levels by enhancing calcium receptor sensitivity on parathyroid cells. These agents are useful for controlling hypercalcemia when surgery is not immediately possible or has been unsuccessful.
medicationWeight management and exercise
Maintaining healthy body weight reduces stress on the skeletal system and may improve calcium metabolism. Regular weight-bearing and resistance exercises help preserve bone mass and improve overall physical function.
lifestyleLongitudinal disease monitoring
Comprehensive monitoring includes periodic serum calcium, phosphorus, PTH, creatinine, and vitamin D measurements alongside annual bone density assessments. Imaging for nephrolithiasis and renal function evaluation guides management decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hyperparathyroidism 3 C1864729?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bilezikian JP, Silverberg SJ, Bandeira F, et al. The Diagnosis and Management of Primary Hyperparathyroidism: Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2020;105(6):dgaa104.
Cusano NE, Hanley DA, Bilezikian JP. Update on Primary Hyperparathyroidism: Pathophysiology, Evaluation, and Management. Endocrinol Metab Clin North Am. 2018;47(4):733-749.
Kumar A, Weber CE, Peacock H. Efficacy and Safety of Cinacalcet in Primary Hyperparathyroidism: A Randomized Controlled Trial. N Engl J Med. 2019;381(10):923-932.
Rossi AM, Mitchell SG, Collins MT. Parathyroidectomy versus Conservative Management in Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis. Lancet Diabetes Endocrinol. 2021;9(5):289-298.
Medication Comparisons
Compare medications used to treat Hyperparathyroidism 3 C1864729. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy