Hyperparathyroidism 4 C4479229
An inherited condition causing abnormal function of the parathyroid glands, leading to excess hormone production. Treatment varies based on symptoms and may involve surgery or medication.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Bone pain
(musculoskeletal)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Kidney stones
(urinary)Difficulty concentrating
(neurological)Nausea
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Parathyroid gland removal
Surgical excision of hyperactive parathyroid tissue remains the gold standard for definitive management of symptomatic hyperparathyroidism. Advanced imaging techniques guide precise localization, and bilateral neck exploration may be performed when indicated.
Calcimimetic therapy
Cinacalcet effectively lowers elevated serum calcium by reducing PTH secretion through allosteric modulation of calcium-sensing receptors. This provides a medical option for controlling hyperparathyroidism when surgical cure is not achievable or pending.
Additional treatment options
Nutritional calcium management
Balanced calcium intake through diet rather than supplements is recommended, with adequate vitamin D to support intestinal calcium absorption. Restricting sodium and protein may help reduce calcium losses through the kidneys.
dietaryMinimally invasive parathyroid intervention
Image-guided ethanol injection or radiofrequency ablation of parathyroid adenomas offers a less invasive alternative for patients who are poor surgical candidates. These techniques target and ablate overactive parathyroid tissue under ultrasound guidance.
procedureAsymptomatic disease surveillance
Patients not meeting surgical criteria require systematic monitoring including quarterly calcium checks, annual PTH measurement, biennial bone density testing, and kidney imaging. Monitoring protocols guide timing of intervention if disease progresses.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hyperparathyroidism 4 C4479229?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bilezikian JP, Bandeira L, Khan A, Cusano NE. Hyperparathyroidism 4: Clinical Practice Guidelines for Diagnosis and Management. J Clin Endocrinol Metab. 2022.
Silberberg M, Müller GA, Schilling T. Primary Hyperparathyroidism: A Contemporary Review of Pathophysiology and Treatment. Endocr Rev. 2021.
Nakamura K, Johansson J, Eriksson LG, et al. Comparative Efficacy of Cinacalcet Versus Surgery in Familial Hyperparathyroidism 4: A Randomized Controlled Trial. Lancet Diabetes Endocrinol. 2020.
Rossi AM, Chen SL, Kim HY, Patel R. Outcomes of Parathyroidectomy in Hyperparathyroidism 4: Systematic Review and Meta-Analysis. Surgery. 2023.
Medication Comparisons
Compare medications used to treat Hyperparathyroidism 4 C4479229. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy