Hyperphosphatasia With Intellectual Disability Syndrome 6 C4225201
A rare inherited condition with elevated alkaline phosphatase, intellectual disability, and skeletal abnormalities. Care involves symptom management and supportive therapies.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Intellectual disability
(neurologic)Developmental delay
(neurologic)Facial dysmorphism
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Functional Mobility Training
Individualized physical therapy program targeting balance, gait training, and functional movements to maintain mobility and prevent deconditioning.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Individualized Behavioral Support
Person-centered behavioral interventions addressing specific challenges, promoting positive behaviors, and providing emotional support appropriate to cognitive level.
Additional treatment options
Skeletal Health Monitoring
Serial measurement of alkaline phosphatase, skeletal surveys if indicated, and monitoring for bone pain or fracture risk.
monitoringSensory Integration Therapy
Sensory-based interventions to address sensory processing difficulties that may impact behavior, learning, and daily function.
complementaryStructured Daily Routine
Implementation of consistent daily schedules and structured environments to support predictability, reduce anxiety, and promote skill generalization.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Hyperphosphatasia With Intellectual Disability Syndrome 6 C4225201?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy