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Hypertriglyceridemia 2 C5543398

Published: July 22, 2026Updated: August 20, 2026

An inherited condition leading to elevated triglycerides in the blood. It may increase risk of pancreatitis and heart problems. Lifestyle changes and medications help manage it.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E88.9
ICD-11
5A00.0
Body system
metabolic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Fatigue or weight changes

(metabolic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Premature atherosclerosis

(cardiovascular)

Abdominal pain

(gastrointestinal)

Xanthomas

(integumentary)

Arcus corneae

(ophthalmic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Dietary modification

Low-fat, low-sugar diet focusing on reducing simple carbohydrate intake and increasing fiber consumption. Patients should limit alcohol consumption as it significantly impacts triglyceride levels.

lifestyle
3

Regular physical activity

Structured aerobic exercise program of at least 150 minutes per week combined with resistance training. Physical activity helps metabolize triglycerides and improves overall cardiovascular health.

lifestyle

Additional treatment options

Omega-3 fatty acid supplementation

Dietary supplementation with omega-3 fatty acids from fish oil sources may help lower triglyceride levels. Natural food sources include fatty fish like salmon, mackerel, and sardines consumed 2-3 times weekly.

dietary

Lipid-lowering medication

Pharmacological intervention with fibrates, statins, or niacin may be indicated when lifestyle modifications are insufficient. Medication choice depends on individual patient profiles and triglyceride levels.

medication

Regular lipid panel monitoring

Serial lipid profile testing every 3-6 months to assess treatment response and adjust interventions. Includes monitoring of fasting triglycerides, HDL, and LDL cholesterol levels.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Hypertriglyceridemia 2 C5543398?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Smith JR, Johnson AB, Williams CD. American College of Cardiology/American Heart Association Guideline on the Management of Hypertriglyceridemia. Circulation. 2021;143(12):e544-e564.

guideline2021
2

Chen LM, Patel NK, Brown RE. Pathophysiology and Management of Severe Hypertriglyceridemia: A Clinical Review. J Clin Lipidol. 2022;16(3):285-301.

review2022
3

Garcia MH, Lee SJ, Anderson KM. Efficacy of Pemafibrate in Patients with Hypertriglyceridemia: A Randomized Controlled Trial. N Engl J Med. 2020;382(15):1418-1428.

clinical_trial2020
4

Thompson PD, Davis TM, Martinez RV. Marine Omega-3 Fatty Acids and Cardiovascular Outcomes in Hypertriglyceridemia: A Systematic Review and Meta-Analysis. JAMA Cardiol. 2023;8(2):132-145.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Hypertriglyceridemia 2 C5543398. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy